Dimetacrine

Dimetacrine

Systematic (IUPAC) name
3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine
Clinical data
Legal status	℞ (Prescription only)
Routes of administration	Oral
Identifiers
CAS Number	4757-55-5
ATC code	N06AA18 (WHO)
PubChem	CID: 94280
DrugBank	DB08996 Y
ChemSpider	85085
UNII	O341NY501N Y
KEGG	D02565
Chemical data
Formula	C20H26N2
Molecular mass	294.43 g/mol
SMILES CC1(C2=CC=CC=C2N(C3=CC=CC=C31)CCCN(C)C)C

Dimetacrine (Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression. It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests. Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).