Atipamezole

Atipamezole
Systematic (IUPAC) name
	4-(2-Ethyl-1,3-dihydroinden-2-yl)-3H-imidazole
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	Veterinary use only;
Identifiers
CAS Number	104054-27-5
ATCvet code	QV03AB90 (WHO)
PubChem	CID: 71310
ChemSpider	64427
UNII	03N9U5JAF6
KEGG	D03002
ChEMBL	CHEMBL353972
Chemical data
Formula	C14H16N2
Molecular mass	212.290 g/mol
	SMILES n1cc(nc1)C3(Cc2c(cccc2)C3)CC ;
	InChI InChI=1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16) ; Key:HSWPZIDYAHLZDD-UHFFFAOYSA-N ;
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Atipamezole (brand name Antisedan, Pfizer) is a synthetic α₂ adrenergic receptor antagonist, indicated for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs.^[1]

It has also been researched in humans as a potential anti-Parkinsonian drug.^[2]

Dosing

In a study using New Zealand white rabbits, the optimal dose for revival of sedation by a medetomidine-ketamine mixture was found to be equal to or double the dose of medetomidine. ^[3]

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