Xanomeline

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Xanomeline
File:Xanomeline.png
Systematic (IUPAC) name
3-(4-Hexoxy-1,2,5-thiadiazol-3-yl)-1-methyl-5,6-dihydro-2H-pyridine
Identifiers
CAS Number 131986-45-3
ATC code None
PubChem CID: 60809
IUPHAR/BPS 57
ChemSpider 54797
UNII 9ORI6L73CJ YesY
KEGG D06330
ChEMBL CHEMBL21536
Chemical data
Formula C14H23N3OS
Molecular mass 281.42 g/mol
  • CCCCCCOC1=NSN=C1C2=CCCN(C2)C

Xanomeline (LY-246,708; Lumeron, Memcor) is a muscarinic acetylcholine receptor agonist with reasonable selectivity for the M1 and M4 subtypes,[1][2][3][4] though it is also known to act as a M5 receptor antagonist.[5] It has been studied for the treatment of both Alzheimer's disease and schizophrenia, particularly the cognitive and negative symptoms,[6] although gastrointestinal side effects led to a high drop-out rate in clinical trials.[7][8] Despite this, xanomeline has been shown to have reasonable efficacy for the treatment of schizophrenia symptoms, and one recent human study found robust improvements in verbal learning and short-term memory associated with xanomeline treatment.[9]

See also

References

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  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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