Pardoprunox

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Pardoprunox
Pardoprunox.png
Systematic (IUPAC) name
7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one
Clinical data
Legal status
  • Uncontrolled
Routes of
administration		 Oral
Identifiers
CAS Number 269718-84-5
ATC code none
PubChem CID: 6918524
ChemSpider 5293721
UNII 5R72CHP32S YesY
Chemical data
Formula C12H15N3O2
Molecular mass 269.73 g/mol
  • Cl.O=C2Oc1c(cccc1N2)N3CCN(C)CC3

Pardoprunox (INN) (code name SLV-308) is an antiparkinsonian drug currently that was under development by Solvay for the treatment of Parkinson's disease that reached phase III clinical trials before being discontinued.[1][2][3][1] It was also being investigated for the treatment of depression and anxiety but these indications appear to have been abandoned as well.[1]

Pardoprunox acts as a D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA = 100%).[1][4] It also binds to D4 (pKi = 7.8), α1-adrenergic (pKi = 7.8), α2-adrenergic (pKi = 7.4), and 5-HT7 receptors (pKi = 7.2) with lower affinity.[1][4] Relative to other dopaminergic antiparkinsonian agents, pardoprunox is thought to have significantly less of a propensity for inducing certain side effects like dyskinesia and psychosis.[4][5]

See also

References

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Further reading

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