WAY-181,187

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WAY-181,187 is a high affinity and selective 5-HT6 receptor full agonist.[1][2] It induces robust increases in extracellular GABA levels in the frontal cortex, hippocampus, striatum, and amygdala of rats without affecting concentrations in the nucleus accumbens or thalamus, and has modest to no effects on norepinephrine, serotonin, dopamine, or glutamate levels in these areas.[1][3] WAY-181,187 has demonstrated preclinical efficacy in rodent models of depression, anxiety, and notably obsessive-compulsive disorder,[1][4] though it has also been shown to impair cognition and memory.[3][5]

See also

References

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