Capeserod

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Capeserod
Capeserod.svg
Systematic (IUPAC) name
5-(5-amino-6-chloro-2,3-dihydro-1,4-benzodioxin-8-yl)-3-[1-(2-phenylethyl)piperidin-4-yl]-1,3,4-oxadiazol-2-one
Identifiers
CAS Number 769901-96-4
ATC code None
PubChem CID: 9805719
IUPHAR/BPS 29
ChemSpider 7981479
UNII 8163770L8P
ChEMBL CHEMBL2027925
Chemical data
Formula C23H25ClN4O4
Molecular mass 456.93 g·mol−1
  • C1CN(CCC1N2C(=O)OC(=N2)C3=CC(=C(C4=C3OCCO4)N)Cl)CCC5=CC=CC=C5
  • InChI=1S/C23H25ClN4O4/c24-18-14-17(20-21(19(18)25)31-13-12-30-20)22-26-28(23(29)32-22)16-7-10-27(11-8-16)9-6-15-4-2-1-3-5-15/h1-5,14,16H,6-13,25H2
  • Key:MDBNTXARNGRHEV-UHFFFAOYSA-N

Capeserod (INN,[1] previously known as SL65.0155) is a selective 5-HT4 receptor partial agonist with Ki = 0.6 nM and IA = 40–50% (relative to serotonin).[2] It potently enhances cognition, learning, and memory,[2][3][4][5][6][7] and also possesses antidepressant effects.[8] Capeserod was in phase II clinical trials around 2004–2006 for the treatment of memory deficits and dementia but no new information has surfaced since and it appears to have been abandoned.[9][10]

See also

References

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