SARS-CoV-2 Beta variant

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File:501.V2 variant countries.svg
Countries with confirmed cases of Beta variant as of 25 June 2021[1]
Legend:
  1000+ confirmed sequences
  250–999 confirmed sequences
  100–249 confirmed sequences
  10–99 confirmed sequences
  2–9 confirmed sequences
  1 confirmed sequence
  None or no data available

Beta variant,[1][2] also known as lineage B.1.351,[lower-alpha 1] is a variant of SARS-CoV-2, the virus that causes COVID-19. One of several SARS-CoV-2 variants believed to be of particular importance, it was first detected in the Nelson Mandela Bay[5] metropolitan area of the Eastern Cape province of South Africa in October 2020,[6] which was reported by the country's health department on 18 December 2020.[7] Phylogeographic analysis suggests this variant emerged in the Nelson Mandela Bay already in July or August 2020.[8]

The World Health Organization labelled the variant as Beta variant, not to replace the scientific name but as a name for the public to commonly use.[9][10] The WHO considers it to be a variant of concern.[9]

Mutations

  • SARS-CoV-2 Beta variant.svg

    Amino acid mutations of SARS-CoV-2 Beta variant plotted on a genome map of SARS-CoV-2 with a focus on Spike.[11]

(change of amino acid only)
Mutational profile of Beta variant
Gene Nucleotide Amino acid
ORF1ab C1059T T265I
G5230T K1655N
C8660T H2799Y
C8964T S2900L
A10323G K3353R
G13843T D4527Y
C14408T1 P4715L
C17999T T5912I
Spike C21614T L18F
A21801C D80A
A22206G D215G
G22299T R246I
G22813T K417N
G23012A E484K
A23063T N501Y
A23403G1 D614G
G23664T A701V
ORF3a G25563T Q57H
C25904T S171L
E C26456T P71L
N C28887T T205I

Footnote: 1Presented in parent lineage B.1.

Source: Tegally et al. (2020), supplementary Fig S8

There are three mutations of particular interest in the spike region of the lineage B.1.351 genome:[12]

  • K417N
  • E484K
  • N501Y

and a further five spike mutations which have so far generated less concern:[12]

  • L18F
  • D80A
  • D215G
  • R246I
  • A701V

Away from the spike region, it also carries: K1655N, SGF 3675-3677 deletion, P71L, and T205I.[13]

Scientists noted that the variant is able to attach more easily to human cells because of three mutations in the receptor-binding domain (RBD) in the spike glycoprotein of the virus: N501Y[7][14] (a change from asparagine (N) to tyrosine (Y)[15] in amino-acid position 501), K417N, and E484K.[16][17] Two of these mutations, E484K and N501Y, are within the receptor-binding motif (RBM) of the receptor-binding domain (RBD).[18][19]

The N501Y mutation has also been detected in the United Kingdom.[7][20] Two mutations found in the Beta variant, E484K and K417N, are not found in Alpha variant. Also, Beta does not have the 69-70del mutation found in the other variant.[14][21]

Vaccine efficacy

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See also: Oxford–AstraZeneca COVID-19 vaccine § Effectiveness, Pfizer–BioNTech COVID-19 vaccine § Effectiveness, Janssen COVID-19 vaccine § Efficacy, and Novavax COVID-19 vaccine § Efficacy

On 4 January 2021, UK newspaper The Telegraph reported that Oxford immunologist Sir John Bell believed there was "a big question mark" over the new South African variant's potential resistance to COVID-19 vaccines, raising fears that vaccines might not work as effectively on that variant strain.[22] The same day Shabir Madhi, professor of vaccinology at the University of the Witwatersrand, commented to CBS News that "it's not a given" that the new Beta variant (501.V2 variant) would be able to evade the vaccines, but that it should be considered that they "might not have the full efficacy".[23] The additional mutations to the spike protein in Beta were raised as a concerning factor by Simon Clarke, an associate professor in cellular microbiology at the University of Reading, in that they "may make the virus less susceptible to the immune response triggered by the vaccines".[24] Lawrence Young, a virologist at Warwick University, also noted that the variant's multiple spike mutations "could lead to some escape from immune protection".[24]

The E484K amino acid change, a receptor-binding-domain (RBD) mutation, was reported to be "associated with escape from neutralising antibodies" which could adversely affect the efficacy of spike protein-dependent COVID vaccines.[25][26] The E484K spike mutation was linked to a case of reinfection with the Beta variant of SARS-CoV-2 in Brazil, believed by researchers to be the first such case of reinfection involving this mutation.[27] The possibility of an alteration in antigenicity was referred to as an "escape mutation" from a monoclonal antibody with the capability of neutralizing the spike protein variants of SARS-CoV-2.[28][29] This suggests that existing vaccines can and should be updated to counter the new strains without recourse to phased trials.

Johnson & Johnson

In January, Johnson & Johnson, which held trials for its Ad26.COV2.S vaccine in South Africa, reported the level of protection against moderate to severe COVID-19 infection was 72% in the United States, but 64% in South Africa.[30][31]

Pfizer–BioNTech

On 17 February 2021, Pfizer announced that neutralisation activity was reduced by two thirds for the Beta variant, whilst refraining from making claims about the efficacy of the vaccine in preventing illness as a result of this variant.[32]

On 16 March 2021, The South African Health Products Regulatory Authority (SAHPRA) approved the Pfizer-BioNTech vaccine (BNT162b2) for section 21 Emergency Use Authorisation.[33]

File:Covid19 vaccine biontech pfizer 3.jpg
Pfizer–BioNTech vaccine

On 1 April 2021, an update on a South African vaccine trial stated that the vaccine was 100% effective so far (i.e., vaccinated participants saw no cases), with six of nine infections in the placebo control group being the Beta variant (lineage B.1.351).[34] However, nine days later, an Israeli study found that the variant was present even in people who had received both shots of the vaccine, its prevalence a disproportionate, eight-fold increase amongst vaccinated individuals in comparison to wild strains.[35]

On 5 May 2021, a letter summarizing results from the Qatar National Study Group for COVID-19 Vaccination showed 75% effectiveness against infection, with zero cases of severe disease.[36]

Oxford–AstraZeneca

On 6 February 2021, The Financial Times reported that provisional trial data from a study undertaken by South Africa's University of the Witwatersrand in conjunction with Oxford University demonstrated reduced efficacy of the Oxford–AstraZeneca COVID-19 vaccine (AZD1222) against the Beta variant. The study found that in a sample size of 2,000 the AZD1222 vaccine afforded only "minimal protection" in all but the most severe cases of COVID-19.[37]

On 7 February 2021, the South African government suspended the planned deployment of around 1 million doses of the vaccine whilst they examined the data and awaited advice on how to proceed.[38] The South African government subsequently cancelled the use of the vaccine, selling its supply to other African countries, and switched its vaccination program to use the Janssen COVID-19 vaccine.[39][40]

In July 2021, following increased incidence of Beta in France, the United Kingdom - a major user of the AstraZeneca vaccine - placed additional restrictions on people travelling to the UK from France. However, the incidence in France is in its Indian Ocean territory of La Réunion,[41] as pointed out by French politician and doctor Veronique Trillet-Lenoir.[42]

BBIBP-CorV

Other African countries have begun the roll out BBIBP-CorV from Sinopharm, with Morocco, Egypt, The Seychelles and Zimbabwe starting the mass rollout.[43] So far, the vaccine has proven resistant to the Beta variant, as demonstrated in Zimbabwe.[44] On 2 February 2021, a preprint paper announced that neutralisation activity was reduced by 1.6 fold for the Beta variant.[45]

Moderna

In February, Moderna reported that the current vaccine (mRNA-1273) produced only one sixth of the antibodies in response to the South African variant compared with the original virus. They have launched a trial of a new vaccine to tackle the Beta variant.[46]

Sputnik V

The South African Health Products Regulatory Authority (SAHPRA) has confirmed that it has received documentation for the vaccine developed by the Gamaleya Institute in Russia.[47]

Sputnik V (Gam-COVID-Vac) is one of three Covid vaccines worldwide with an efficacy higher than 90% in symptomatic cases. It was found to be slightly less effective however it worked better than its rivals.[1] A three fold reduction in VNA was found against the beta variant. [2] [3]

CoronaVac

CoronaVac is yet to be approved for use by the South African Health Products Authority (SAHPRA).[48] So far, Sinovac has offered to supply South Africa with 5 million doses of the vaccine.[49]

Covaxin

Covaxin has been found to be effective against the beta variant although with a three fold reduction in neutralization.

CoviVac

The CoviVac vaccine Information has not been delivered to the South African government yet.[50]

EpiVacCorona

The EpiVacCorona vaccine Information has not been delivered to the South African government yet.[51]

ZF2001

The ZF2001 vaccine Information is in the process of being delivered to the South African government.[52]

Novavax

A study on the NVX-CoV2373 Novavax vaccine showed 60% efficacy (for HIV-negative participants) in South Africa, compared to 90% efficacy in Britain.[53]

ImmunityBio

The BioVac Institute, a state-backed South African vaccine company, plans to use a deal it won to manufacture coronavirus vaccines. The contract with American based ImmunityBio Inc is currently conducting phase 1 vaccine trials with their hAd5 vaccine in the United States and South Africa.[54]

ImmunityBio and BioVac plan to distribute the vaccines throughout South Africa and Africa.[55][56]

Epidemiology

Researchers and officials reported that the prevalence of the variant was higher among young people with no underlying health conditions, and more frequently causes serious illness in such cases than other variants.[57][58] The South African health department also indicated that the variant may be driving the second wave of the COVID-19 pandemic in the country, as the variant spreads faster than other earlier variants of the virus.[7][57]

Statistics

Cases by country (Updated as of 1 July 2021) GISAID[1]
Country Confirmed cases Last Reported Case
Angola 385 22 April 2021
Argentina 1 24 April 2021
Aruba 4 10 April 2021
Australia 65 28 June 2021
Austria 260 8 June 2021
Bahrain 1 9 April 2021
Bangladesh 41 16 June 2021
Belgium 1,004 14 June 2021
Botswana 325 27 June 2021
Brazil 5 5 April 2021
Brunei 1 20 January 2021
Bulgaria 1 9 June 2021
Cambodia 1 31 May 2021
Cameroon 9 1 March 2021
Canada 822
Chile 3 22 May 2021
China 96 4 June 2021
Colombia 1 13 April 2021
Costa Rica 12 4 May 2021
Cote d'Ivoire 1 6 March 2021
Croatia 41
Czech Republic 65 10 June 2021
Democratic Republic of the Congo 13 20 April 2021
Denmark 113 29 June 2021
Djibouti 22 9 April 2021
Equatorial Guinea 43 1 April 2021
Estonia 37 23 April 2021
Eswatini 26 23 March 2021
Finland 1,096 21 May 2021
France 2,053 23 June 2021
French Guiana 1 7 April 2021
Gabon 4 21 February 2021
Germany 2,185 19 June 2021
Ghana 12 8 April 2021
Greece 22 29 April 2021
Guadeloupe 4 25 May 2021
Guam 3 28 April 2021
Guinea Bissau 1 1 February 2021
India 215 14 June 2021
Indonesia 7 2 June 2021
Iran 2 3 April 2021
Iraq 1 26 February 2021
Ireland 69 19 April 2021
Israel 240 28 May 2021
Italy 46 1 June 2021
Japan 78 13 June 2021
Jordan 2 18 April 2021
Kenya 177 31 May 2021
Latvia 9 13 May 2021
Lesotho 14 18 January 2021
Lithuania 11 9 April 2021
Luxembourg 745 22 May 2021
Malawi 313 16 April 2021
Malaysia 152 10 June 2021
Malta 3 1 June 2021
Martinique 2 28 April 2021
Mauritius 8 12 March 2021
Mayotte 33 31 January 2021
Mexico 19 16 May 2021
Mozambique 319 22 April 2021
Namibia 9
Netherlands 689 27 May 2021
New Zealand 29 25 June 2021
North Macedonia 1 10 March 2021
Norway 359 11 June 2021
Pakistan 30 5 June 2021
Panama 2 12 January 2021
Philippines 693 8 April 2021
Poland 45 7 June 2021
Portugal 96 2 June 2021
Qatar 468 18 May 2021
Reunion 351 19 June 2021
Romania 7 26 May 2021
Russia 22 12 June 2021
Rwanda 31 15 June 2021
Saudi Arabia 1 15 April 2021
Singapore 96 25 June 2021
Sint Maarten 1 24 March 2021
Slovakia 28 27 May 2021
Slovenia 31 6 April 2021
South Africa 6,023 21 June 2021
South Korea 17 17 April 2021
Spain 274 18 June 2021
Sri Lanka 4 26 March 2021
Suriname 5 31 March 2021
Sweden 2,280 17 June 2021
Switzerland 223 22 June 2021
Taiwan 3 26 April 2021
Thailand 36 25 May 2021
Togo 2 5 February 2021
Tunisia 1 24 April 2021
Turkey 539 24 May 2021
Uganda 13 2 April 2021
United Arab Emirates 6 27 April 2021
United Kingdom 808 24 June 2021
USA 2,276 28 June 2021
Zambia 161 28 April 2021
Zimbabwe 331 26 February 2021
World (98 countries) Total: 27,235 Total as of 6 July 2021

History

A genomics team lead by the KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP) at the University of KwaZulu-Natal discovered the new variant.[59] It was uncovered by whole genome sequencing. Several genomic sequences from this lineage were submitted to the GISAID sequence database.[60][better source needed]

On 23 December, UK health minister Matt Hancock announced that two people who had travelled from South Africa to the UK were infected with the Beta variant (501.V2 variant).[21][61] On 28 December, the variant had been detected in two people in Switzerland[62] and in one in Finland.[63] On 29 December, the strain had been detected in a visitor from South Africa to Japan,[64] and in one overseas traveller to Queensland, Australia.[65] On 30 December the variant was detected in Zambia.[66] On 31 December, it was also detected in France, in a passenger returning from South Africa.[67] On 2 January 2021, the first case of this variant was detected in South Korea.[68] Austria reported their first case of this variant, along with four cases of the Alpha variant on 4 January.[69] The Republic of Botswana also detected their first case on 4 January.[70] The People's Republic of China reported the first case of this variant in southern Guangdong province on 6 January.[71]

On 8 January 2021, the Republic of Ireland reported the detection of 3 cases, all linked to travel from South Africa.[72] On the same day a case of reinfection with the new variant by a woman who had had COVID-19 was reported from Brazil, the first such reinfection reported in the world.[27] Canada reported the first case of this variant in Alberta on 9 January,[73] and Israel reported four cases, all of which were imported in people travelling from South Africa.[74] New Zealand reported the first case of this variant on 10 January.[75][76] On 12 January, Germany reported the detection of the mutation in six people from three different households.[77] The same day, it was reported that the United Kingdom had a total of 29 cases, two of which were previously reported.[78] The following day, Belgium reported the first case in a person from West Flanders with no travel history,[79] Israel reported four further cases,[80] and Taiwan reported the first case in a Swazi man in his 30s who had tested positive for COVID-19 on 1 January.[81]

On 14 January, Germany detected a further case[82] and the following day, Canada reported a second case of the mutation which was detected in the Canadian province of British Columbia.[83] A further case was reported in Germany the same day.[84] Denmark and Réunion reported their first cases on 16 January as Israel discovered a further four cases.[85][86][87] On 17 January, Israel reported another four cases bringing their total number of cases of this variant to 20.[88] Two further cases were reported in The Netherlands on 18 January bringing the country's total to three.[89] Ghana reported its first case of the variant on 19 January.[90] On 23 January, Panama detected its first case of the strain in a person from Zimbabwe, who had travelled from South Africa.[91] Also on 23 January, Belgium reported at least 15 cases of the variant in Ostend,[92] while 6 cases were confirmed in the Comoros.[93] On 26 January, the Republic of Ireland reported the detection of 6 further cases.[94] The United States reported its first cases of the variant on 28 January 2021, in the state of South Carolina.[95] On 27 January, Israel reported 3 more cases which were the first cases of the variant from samples that were collected in the community randomly, without knowing the source of infection.[96] Preliminary data reported by Africa CDC on 29 January indicated that the variant had reached Ghana.[97] On 31 January, Israel reported its first case of reinfection with the new variant by a man who returned from Turkey.[98]

On 1 February 2021, the United Kingdom Secretary of State for Health and Social Care reported the random detection of 11 cases of the variant where there was no connection to international travel.[99] The same day, the Canadian province of Ontario reported the first case of the variant in the Peel Region, with a similar absence of travel history and no contact with anyone who had recently been abroad.[100] On 8 February, the Republic of Ireland reported the detection of 2 further cases.[101]

On 8 February 2021, Austria detected the greatest outbreak of Beta variant in Europe so far. A total of 293 confirmed cases and 200 suspected cases have been identified through sequencing, most of them will be confirmed in all probability. All of the cases were found in the Tirol region, where nearly 9% of the positive PCR tests were identified as the Beta variant by sequencing.[102] The active cases were estimated at around 140. After a week of public discussion and political pressure about a possible quarantine of Tirol, the government of Austria abstained from isolating the areas of concern, instead making a formal plea to reduce movement in and out of the region and go for testing after visiting Tirol.[103] Tirolean officials stated their intention to relax the lockdown rules in Tirol in keeping with the rest of Austria.[104]

On 22 February, the Israeli Health Ministry stated that the variant had been genetically sequenced in just under 1% of 3,000 community samples.[105] Later on, Israel reported a total of 444 cases of the variant, making it the highest infection rate in the world outside South Africa.[106] On 25 February, the Republic of Ireland reported the detection of 4 further cases.[107] By late February, Turkey had 49 cases of the Beta variant.[108]

On 3 March 2021, the Philippines confirmed its first 6 new cases of the South African variant, with 3 patients from Pasay with no travel history, and 3 with travel histories from Qatar and UAE.[109] On 5 March 2021, Romania reported its first two cases of the South African variant, coming from two patients in Bucharest and Pitești.[110]

On 23 March 2021, Lithuania confirmed its first 2 new cases of the South African strain, 1 in Kaunas county and 1 in Vilnius. There are 10 more suspected cases of it. The infected people said, that they didn't travel anywhere.[111] On 26 March there were 3 more cases confirmed, which means that virus is successfully spreading inside.

On 1 April 2021, Malaysia detected its first cases of South African variant. The health ministry reported two cases believed to originate from the Jalan Lima cluster, involving an employee based at the Kuala Lumpur International Airport (KLIA), with other reported cases sparsely detected within Selangor.[112] As of 1 April, a total of nine cases involving the variant is reported.[113] By 2 May, a total of 48 cases has been detected in least 5 clusters and from contact tracing, of which 20 were found in two clusters in Perak and Kelantan.[114]

On 12 April 2021 Turkey had 285 cases in 11 provinces.[115]

See also

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Notes

  1. ↑ Other names include:[3][4]
    – 20H/501Y.V2 (formerly 20C/501Y.V2)
    – 501Y.V2 variant
    – South African COVID-19 variant

References

  1. ↑ 1.0 1.1 1.2 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ For a list of sources, see South African COVID-19 variant.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ 7.0 7.1 7.2 7.3 Lua error in package.lua at line 80: module 'strict' not found.
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  11. ↑ Spike Variants: Beta variant, aka B.1.351, 501Y.V2, 20C/501Y.V2, and South African COVID-19 variant 24 June 2021, covdb.stanford.edu, accessed 1 July 2021
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  15. ↑ For a list of the symbols used for the α-amino acids incorporated into protein under mRNA direction, see: Lua error in package.lua at line 80: module 'strict' not found.
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  41. ↑ https://www.thelocal.fr/20210717/how-widespread-in-france-is-the-beta-variant-of-covid/
  42. ↑ https://www.independent.co.uk/travel/news-and-advice/france-amber-plus-covid-quarantine-b1885811.html
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  96. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  101. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  102. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  103. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  104. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  105. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  106. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  107. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  108. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  110. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  111. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  112. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  113. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  114. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  115. ↑ Lua error in package.lua at line 80: module 'strict' not found.

External links

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