Mark A. Lemmon
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| Thesis | Specific interactions between transmembrane alpha-helices: Their role in the oligomerization of integral membrane proteins (1993) |
| Doctoral advisor | Donald Engelman |
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Mark Andrew Lemmon FRS[2] is the David A. Sackler Professor of Pharmacology at Yale University where he co-directs the Cancer Biology Institute with Joseph Schlessinger.[1][3]
Education
Lemmon was educated first at Norwich School, and then at Hertford College, Oxford, from which he graduated with a first class Bachelor of Arts degree in Biochemistry in 1988.[3] He completed his PhD at Yale University supervised by Donald Engelman[4] for research on the oligomerization of transmembrane α-helices.[5] Following his PhD, Lemmon was a postdoctoral researcher at New York University in the laboratory of Joseph Schlessinger.[6]
Research and career
Following his postdoctoral studies, Lemmon was recruited to the Department of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine, where he gained tenure in 2001 and became Departmental Chair in 2008.
Lemmon's research combines biochemistry and structural biology with cell biology, focusing on understanding molecular mechanisms of transmembrane signalling by cell-surface growth factor receptors such as the epidermal growth factor (EGF) receptor[1][2] and receptor tyrosine kinases.[7]
Lemmon has made important contributions to the discovery of both normal and pathological activation mechanisms of growth factor receptors and the signalling networks that they engage within cells. He is also committed to exploiting this understanding clinically. These receptors and their downstream effectors are activated aberrantly in numerous cancers, and are important targets of cancer drugs. Lemmon’s recent work has focused on the need to understand the biochemistry of oncogenic activation to use such drugs effectively.[2]
Before moving to Yale, Lemmon was George W. Raiziss Professor and Chair of Biochemistry and Biophysics in the Perelman School of Medicine at the University of Pennsylvania.[2][8] His research has been funded by the National Cancer Institute and the National Institute of General Medical Sciences.[6]
Lemmon serves on the editorial boards of several journals, including Cell,[9] and Molecular Cell.[10] He is also Deputy Chair and Vice Chair for the Americas for the Biochemical Journal.[11] Between 2007 and 2013, Lemmon was Secretary of the American Society for Biochemistry and Molecular Biology.
Awards and honours
Lemmon was elected a Fellow of the Royal Society (FRS) in 2016.[2]
References
- ↑ 1.0 1.1 1.2 1.3 Mark A. Lemmon's publications indexed by Google Scholar, a service provided by Google
- ↑ 2.0 2.1 2.2 2.3 2.4 Lua error in package.lua at line 80: module 'strict' not found. One or more of the preceding sentences incorporates text from the royalsociety.org website where: <templatestyles src="Template:Blockquote/styles.css" />
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived September 25, 2015)
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- ↑ 6.0 6.1 Mark Andrew Lemmon's Entry at ORCID
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