Harry J. Gilbert

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For other people called Harry Gilbert, see Harry Gilbert.
Harry Gilbert
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Scientific career
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Thesis Studies on native and mutant forms of IMP dehydrogenase in Escherichia coli K12 (1979)
Website
www.ncl.ac.uk/camb/staff/profile/harrygilbert.html
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Harry J. Gilbert FRS[2] FMedSci is Professor of Agricultural Biochemistry and Nutrition in the Institute For Cell and Molecular Biosciences at Newcastle University.[1][3]

Education

Gilbert was educated at the University of Southampton graduating with a Bachelor of Science degree in 1975[3] followed by a PhD for research investigating mutant forms of the enzyme IMP dehydrogenase in Escherichia coli K12 in 1979.[4]

Research

Since taking up a lectureship at Newcastle University in 1985 Gilbert’s research has focussed on enzymes, primarily glycoside hydrolases, which attack complex carbohydrates. These enzymes are of considerable biological and industrial importance. Gilbert has used structure-function studies to dissect the contribution of non-catalytic carbohydrate binding modules (CBMs)[5] in targeting enzymes to complex insoluble structures exemplified by the plant cell wall, thereby overcoming the access problem.[6][7]

He has extended his studies on carbohydrate binding modules to explore how glycoside hydrolases are able to select specific substrates and modes of action. Using structure-based strategies, he has exploited this fundamental understanding of enzyme specificity to engineer novel catalytic functions into these biological catalysts.

As of 2016, Gilbert has been dissecting the mechanisms of glycans utilization by gut bacteria, in the human microbiota.[8] His work has led to the presentation of a selfish model for the metabolism of highly complex carbohydrates by members of this ecosystem.[9][10] His work has implications on resource allocation within the human microbiota, which could impact on dietary strategies that maximise the impact of this microbial ecology on health.

From 2008 to 2010 he was appointed an Eminent Scholar in Bioenergy at the University of Georgia, in the USA.[11] Gilbert's research has been funded by the Agricultural and Food Research Council (AFRC), the Biotechnology and Biological Sciences Research Council (BBSRC), the National Science Foundation (NSF), the United States Department of Energy (DOE), the National Institutes of Health (NIH), the Wellcome Trust and the European Research Council (ERC).[11]

Awards and honours

Gilbert was elected a Fellow of the Royal Society (FRS) in 2016[2] and a Fellow of the Academy of Medical Sciences.[when?]

References

  1. ↑ 1.0 1.1 1.2 Harry J. Gilbert's publications indexed by Google Scholar, a service provided by Google
  2. ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found. One or more of the preceding sentences incorporates text from the royalsociety.org website where: <templatestyles src="Template:Blockquote/styles.css" />

    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived September 25, 2015)

  3. ↑ 3.0 3.1 Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found. open access publication - free to read
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  11. ↑ 11.0 11.1 Harry Gilbert's Entry at ORCID

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