SPG21
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Maspardin is a protein that in humans is encoded by the SPG21 gene.[1][2][3]
The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4.[3]
Interactions
SPG21 has been shown to interact with CD4.[1]
References
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<references />, or <references group="..." />Further reading
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