SLC26A8

Solute carrier family 26 (anion exchanger), member 8
Identifiers
Symbols	SLC26A8 ; SPGF3; TAT1
External IDs	OMIM: 608480 MGI: 2385046 HomoloGene: 27095 GeneCards: SLC26A8 Gene
Gene ontology Molecular function • chloride channel activity • protein binding • secondary active sulfate transmembrane transporter activity • sulfate transmembrane transporter activity • anion:anion antiporter activity • oxalate transmembrane transporter activity Cellular component • plasma membrane • integral component of membrane Biological process • anion transport • chloride transport • multicellular organismal development • sulfate transport • oxalate transport • sperm motility • sperm capacitation • meiotic cell cycle • sulfate transmembrane transport • chloride transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116369	224661
Ensembl	ENSG00000112053	ENSMUSG00000036196
UniProt	Q96RN1	Q8R0C3
RefSeq (mRNA)	NM_001193476	NM_001290320
RefSeq (protein)	NP_001180405	NP_001277249
Location (UCSC)	Chr 6: 35.94 – 36.02 Mb	Chr 17: 28.64 – 28.69 Mb
PubMed search	[1]	[2]

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.

Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.

Interactions

SLC26A8 has been shown to interact with RACGAP1.