Relaxin receptor
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The relaxin receptors are a subclass of four closely related G protein-coupled receptors that bind relaxin peptide hormones.[1][2]
Below is list of human relaxin receptors, their endogenous peptide hormones, and what down stream enzymes are activated or inhibited by the receptor.
| receptor/gene | ligands | activates | inhibits |
|---|---|---|---|
| RXFP1 | relaxin 1, relaxin 2, relaxin 3 | adenylate cyclase, protein kinase A, protein kinase C,
phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2) |
|
| RXFP2 | relaxin 1, relaxin 2, insulin-like 3 | adenylate cyclase | |
| RXFP3 | relaxin 3 | Erk1/2 signaling | adenylate cyclase |
| RXFP4 | relaxin 3, insulin-like 3 | adenylate cyclase |
See also
- Relaxin family peptide hormones
- Insulin/IGF/Relaxin family
- Relaxin/insulin-like family peptide receptor 1
References
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<references />, or <references group="..." />External links
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- relaxin receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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