Prinaberel

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Prinaberel
Prinaberel.svg
Systematic (IUPAC) name
(4Z)-2-Fluoro-4-(5-hydroxy-7-vinyl-1,3-benzoxazol-2(3H)-ylidene)-2,5-cyclohexadien-1-one
Identifiers
CAS Number 524684-52-4
ATC code None
PubChem CID: 5326893
ChemSpider 4484184
Chemical data
Formula C15H10FNO3
Molecular mass 271.243 g/mol
  • O=C3\C=C/C(=C2/Oc1c(cc(O)cc1N2)\C=C)/C=C3/F
  • InChI=1S/C15H10FNO3/c1-2-8-5-10(18)7-12-14(8)20-15(17-12)9-3-4-13(19)11(16)6-9/h2-7,17-18H,1H2/b15-9-
  • Key:FCXYSEXZEGPLGG-DHDCSXOGSA-N

Prinaberel (INN, USAN) (developmental code names ERB-041, WAY-202041) is a synthetic, non-steroidal, and highly selective agonist of the ERβ subtype of the estrogen receptor.[1] It is used in scientific research to elucidate the role of the ERβ receptor.[2] Studies have indicated that selective ERβ agonists like prinaberel could be useful in the clinical treatment of a variety of medical conditions including inflammatory bowel disease, rheumatoid arthritis, endometriosis, and sepsis.[3] Accordingly, prinaberel either was or still is under investigation by Wyeth for the treatment of some of these conditions.[4]

As of 2015, prinaberel is the only synthetic, selective ERβ agonist to have reached human clinical trials.[5]

See also

References

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External links



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