Orexin antagonist
From Infogalactic: the planetary knowledge core
An orexin receptor antagonist is a drug that inhibits the effect of orexin by acting as a receptor antagonist of the orexin receptor. Potential applications include treatment of sleep disorders such as insomnia.[1][2]
Examples
- Almorexant, development of the drug was abandoned in January 2011
- Lemborexant
- SB-334,867, has been shown to produce sedative and anorectic effects in animals,[3]
- SB-408,124
- SB-649,868, in development for potential use in sleep disorders
- Suvorexant, approved for use in sleep disorders under the brand name Belsomra
- TCS-OX2-29, OX2 selective
- RTIOX-276, OX1 selective
References
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