KCNK18

Potassium channel, two pore domain subfamily K, member 18
Identifiers
Symbols	KCNK18 ; K2p18.1; MGR13; TRESK; TRESK-2; TRESK2; TRIK
External IDs	OMIM: 613655 MGI: 2685627 HomoloGene: 133808 IUPHAR: 527 GeneCards: KCNK18 Gene
Gene ontology Molecular function • potassium channel activity • calcium-activated potassium channel activity • outward rectifier potassium channel activity • potassium ion leak channel activity Cellular component • plasma membrane • integral component of plasma membrane Biological process • potassium ion transport • synaptic transmission • stabilization of membrane potential • potassium ion export • cellular response to pH Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	338567	332396
Ensembl	ENSG00000186795	ENSMUSG00000040901
UniProt	Q7Z418	Q6VV64
RefSeq (mRNA)	NM_181840	NM_207261
RefSeq (protein)	NP_862823	NP_997144
Location (UCSC)	Chr 10: 117.2 – 117.21 Mb	Chr 19: 59.22 – 59.24 Mb
PubMed search	[1]	[2]

Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K_2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K_2P18.1 is a potassium channel containing two pore-forming P domains.

A flaw in this gene could help trigger migraine headaches. If the gene does not work properly, environmental factors can more easily trigger pain centres in the brain and cause a severe headache.

See also

• Tandem pore domain potassium channel

External links

• KCNK18 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)