Hyoscine butylbromide
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Lua error in Module:Infobox at line 314: malformed pattern (missing ']'). Hyoscine butylbromide, also known as scopolamine butylbromide[1] and sold under the brandname Buscopan,[2] is a medication used to treat crampy abdominal pain, renal colic, and bladder spasms.[2][3] It is also used to improve a death rattle at the end of life.[4] Hyoscine butylbromide can be taken by mouth, injection into a muscle, or into a vein.[2]
Side effects may include sleepiness, vision changes, triggering of glaucoma, and severe allergies.[2] Sleepiness however, is uncommon.[5] It is unclear if it is safe in pregnancy.[2] It is an anticholinergic agent,[2] which does not have much effect on the brain.[6]
It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.[7] It is not available in the United States.[8] The wholesale cost is 0.004 to 0.11 USD per pill as of 2014.[9] It is manufactured from hyoscine which is naturally from the plant deadly nightshade.[10]
Medical uses
Hyoscine butylbromide is effective in treating crampy abdominal pain.[11]
Hyoscine butylbromide is effective in significantly reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate.[12]
Pharmacology
It is a quaternary ammonium compound and a semisynthetic derivative of scopolamine. The attachment of the butyl-bromide moiety effectively prevents the movement of this drug across the blood–brain barrier, effectively minimising undesirable central nervous system side effects associated with scopolamine/hyoscine.
Abuse
Hyoscine butylbromide is not centrally active and has a low incidence of abuse.
Names
Other names include butylscopolamine, scopolamine butylbromide,[1] butylhyoscine, and butylscopolamine bromide.
References
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