GMP reductase
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| guanosine monophosphate reductase | |
|---|---|
| Identifiers | |
| Symbol | GMPR |
| Entrez | 2766 |
| HUGO | 4376 |
| OMIM | 139265 |
| RefSeq | NM_006877 |
| UniProt | P36959 |
| Other data | |
| EC number | 1.7.1.7 |
| Locus | Chr. 6 p23 |
| guanosine monophosphate reductase 2 | |
|---|---|
| Identifiers | |
| Symbol | GMPR2 |
| Entrez | 51292 |
| HUGO | 4377 |
| OMIM | 610781 |
| RefSeq | NM_016576 |
| UniProt | Q9P2T1 |
| Other data | |
| Locus | Chr. 14 q11.2 |
GMP reductase EC 1.7.1.7 (Guanosine 5'-monophosphate oxidoreductase ) is an enzyme that catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP.[1]
NADPH + guanosine 5-phosphate = NADP+ + inosine 5-phosphate + NH3
It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides.
In melanocytic cells, GMP reductase gene expression may be regulated by MITF.[2]
See also
References
External links
- GMP reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the public domain Pfam and InterPro IPR001093
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