David C. Rubinsztein
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| David C. Rubinsztein | |
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David C. Rubinsztein, 2014, University of Cambridge
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| Born | 1963 |
| Fields | Autophagy Cell Biology Neurodegenerative diseases Medical Genetics |
| Institutions | University of Cambridge Cambridge Institute for Medical Research Cambridge Drug Discovery Institute |
| Alma mater | University of Cape Town (BSc(Med)Hons) University of Cape Town (PhD) |
| Thesis | Monogenic Hypercholesterolemia in South Africans (1993) |
| Doctoral advisor | Prof. D.R. van der Westhuyzen |
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David C. Rubinsztein (born 1963) is a Wellcome Trust Principal Research Fellow, the Deputy Director of the Cambridge Institute of Medical Research (CIMR),[1] the Academic Lead of the Alzheimer's Research UK Cambridge Drug Discovery Institute,[2] and Professor of Molecular Neurogenetics at the University of Cambridge.[3]
Education
David C. Rubinsztein completed his Bachelor of Medicine, Bachelor of Surgery (MB ChB) in 1986 and PhD in 1993 in the Medical Research Council/University of Cape Town Unit for the Cell Biology of Atherosclerosis. In 1993 he went to Cambridge as a senior registrar in Genetic Pathology.[4]
Career
In 1997, David C. Rubinsztein acquired his Certificate of Completion of Specialist Training at the University of Cambridge. He was appointed to a Personal Readership at the University of Cambridge in 2003. In 2005, he was promoted to Professor of Molecular Neurogenetics at the University of Cambridge (personal chair). He has been an author on more than 300 scientific papers,[5] and was ranked as the 4th most cited European author from 2007 – 2013 in cell biology.[6] Rubinsztein has been invited to give talks at major international conferences, including Gordon Research Conferences and Keystone Symposia.[7][8][9]
Research
David C. Rubinsztein has made major contributions to the field of neurodegeneration with his laboratory's discovery that autophagy regulates the levels of intracytoplasmic aggregate-prone proteins that cause many neurodegenerative diseases, including Huntington’s, Parkinson’s and Alzheimer’s disease.[10][11][12][13][14] His lab has found that autophagy may be inhibited in various neurodegenerative diseases[15] and has elucidated the pathological consequences of autophagy compromise.[16] In addition his research has advanced the basic understanding of autophagy, identifying the plasma membrane as a source of autophagosome membrane[17] and characterising early events in autophagosome biogenesis,.[18][19][20] Furthermore he studied how lysosomal positioning regulates autophagy.[21] His goal is to understand the links between these diseases and autophagy. He is currently focused on understanding how to induce autophagy in vivo in order to remove toxic proteins and avoid the development of neurodegenerative disease[1][22]
Honours and awards
1997 Glaxo-Wellcome Fellowship
2001 Medical Research Council (MRC) Programme grant, Wellcome Trust Senior Clinical Fellowship
2004 Fellow of the Academy of Medical Sciences[23]
2005 Professor of Molecular Neurogenetics, University of Cambridge
2006 MRC Programme grant, Wellcome Trust Principal Clinical Fellowship[24]
2007 Graham Bull Prize for Clinical Science by the Royal College of Physicians[25]
2012 Wellcome Trust Principal Fellowship
2013 Deputy Director of Cambridge Institute for Medical Research, University of Cambridge
2014 Thomson Reuters' Highly Cited Researchers 2014 in the categories Biology and Biochemistry and Molecular Biology and Genetics[27]
2015 Thomson Reuters' Highly Cited Researchers 2015 in the categories Biology and Biochemistry[27]
2015 Academic Lead of ARUK Cambridge Drug Discovery Institute
2015 4th highest cited cell biologist in Europe and Israel for articles published between 2007-2013 http://www.labtimes.org/labtimes/ranking/2015_05/index.lasso
2016 Awarded Thudichum Medal from Biochemical Society for 2017 http://www.biochemistry.org/Awards/2017Winners.aspx
References
- ↑ 1.0 1.1 Professor David C. Rubinsztein, Cambridge Institute for Medical Research
- ↑ Cambridge Drug Discovery Institute Cambridge
- ↑ Cambridge Neuroscience
- ↑ F1000 Prime Faculty Member
- ↑ Research Gate
- ↑ Publication analysis 2007-2013, Cell Biology
- ↑ Centre for Science and Policy
- ↑ Journal of Biological Chemistry
- ↑ NeurOmics
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Science Watch
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
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- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Sens Research Foundation
- ↑ Academy of Medical Sciences
- ↑ Wellcome Trust
- ↑ Editor biographies
- ↑ EMBO
- ↑ 27.0 27.1 Thomson Reuters
