Central Institute for Experimental Animals

Central Institute for Experimental Animals Acronym: CIEA

Formation	1952
Headquarters	Kawasaki, Kanagawa, Japan
Director	Tatsuji Nomura
Website	http://www.ciea.or.jp/en/index.html

Central Institute for Experimental Animals (CIEA) (実験動物中央研究所) is a research center for experimental animals in Japan. It was founded by Tatsuji Nomura in 1952 with the mission of improving the level of biomedical research.

Main achievements and ongoing projects

• Establishment of the world first and only monitoring center for experimental animals in 1970. Appointed as an International Council for Laboratory Animal Science (ICLAS) Monitoring Center in 1979.
• Development and establishment of Tg-PVR mouse, in which a human poliovirus receptor gene is introduced, used as a safety testing for oral polio vaccine.
• Establishment of Tg-rasH2 mouse, in which a human prototype c-Ha-ras oncogene is introduced, and evaluation of their practical usefulness. Achieved a high level of accuracy in carcinogenicity testing for drugs and reduced the testing period to six months from the conventional two years' system.
• Developing spinal cord injury model and Parkinson's disease model using the common marmoset (New World monkey).
• Establishment of a severe immunodeficient mouse, NOD/Shi-scid, IL-2Rγnull mouse (NOD/SCID/IL-2Rγnull mouse, NOG mouse) and development of its applications to various animal experiments and testing systems.

History

• 1952 Founded in Nishitama District, Tokyo, Japan
• 1957 Authorized as a non-profit research organization under Ministry of Education, Japan
• 1962 Specific Pathogen Free (SPF) animal production facility was established in Nogawa, Kawasaki, Japan
• 1965 Animal production and supply department was spun off as CLEA Japan, Inc.
• 1966 Preclinical Research Laboratory was established
• 1969 Germ-free animal facility was established
• 1973 Bioscience Research Department was established
• 1976 Organized "The 2nd International Workshop on Nude Mice", Tokyo, Chairman T. Nomura
• 1979 Appointed as ICLAS Monitoring Center
• 1982 Embryological Engineering Laboratory was established
• 1985 Laboratory animal monitoring facilities completed
• 1987 Developmental Engineering Experiment Manual published
• 1988 High priority "Laboratory animal monitoring project" started
• 1991 From Six Mice: History of Central Institute for Experimental Animals published
• 1992 Laboratory Animal Cryopreservation Facilities completed
• 2001 Center for the Advancement of Health and Biosciences (CAHB) established as a nonprofit organization in the United States
• 2002 Global business development was initiated
• 2005 NOG mouse patent granted
• 2006 Tatsuji Nomura becomes Chairman of the Board of Directors of CIEA
• 2006 Organized "The 1st International Workshop on Humanized Mice", Tokyo, Chairman T. Nomura

External links

• CIEA website
• Monitoring Center (Japanese)
• Tg-rasH2 mice
• NOG mice