CYP26B1

Cytochrome P450, family 26, subfamily B, polypeptide 1
Identifiers
Symbols	CYP26B1 ; CYP26A2; P450RAI-2; P450RAI2; RHFCA
External IDs	OMIM: 605207 MGI: 2176159 HomoloGene: 23179 GeneCards: CYP26B1 Gene
Gene ontology Molecular function • retinoic acid binding • iron ion binding • retinoic acid 4-hydroxylase activity • heme binding Cellular component • cytoplasm • endoplasmic reticulum membrane Biological process • cell fate determination • establishment of T cell polarity • vitamin metabolic process • xenobiotic metabolic process • inflammatory response • male meiosis • spermatogenesis • proximal/distal pattern formation • positive regulation of gene expression • embryonic limb morphogenesis • retinoic acid catabolic process • tongue morphogenesis • small molecule metabolic process • regulation of T cell differentiation • retinoic acid receptor signaling pathway • negative regulation of retinoic acid receptor signaling pathway • oxidation-reduction process • bone morphogenesis • establishment of skin barrier • cornification • cellular response to retinoic acid • positive regulation of tongue muscle cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CYP26B1 219825 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56603	232174
Ensembl	ENSG00000003137	ENSMUSG00000063415
UniProt	Q9NR63	Q811W2
RefSeq (mRNA)	NM_001277742	NM_001177713
RefSeq (protein)	NP_001264671	NP_001171184
Location (UCSC)	Chr 2: 72.13 – 72.15 Mb	Chr 6: 84.57 – 84.59 Mb
PubMed search	[1]	[2]

Cytochrome P450 26B1 is a protein that in humans is encoded by the CYP26B1 gene.

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid.

CYP26B1 has been shown to be over-expressed in colorectal cancer cells compared to normal colonic epithelium. CYP26B1 expression was also independently prognostic in patients with colorectal cancer and strong expression was associated with a poorer outcome.