Benzylfentanyl

Benzylfentanyl

Names
IUPAC name N-(1-Benzylpiperidin-4-yl)-N-phenylpropanamide
Identifiers
CAS Number	1474-02-8
ChemSpider	220920
Jmol 3D model	Interactive image
PubChem	252141
InChI InChI=1S/C21H26N2O/c1-2-21(24)23(19-11-7-4-8-12-19)20-13-15-22(16-14-20)17-18-9-5-3-6-10-18/h3-12,20H,2,13-17H2,1H3 Key: POQDXIFVWVZVML-UHFFFAOYSA-N
SMILES CCC(=O)N(C1CCN(CC1)CC2=CC=CC=C2)C3=CC=CC=C3
Properties
Chemical formula	C21H26N2O
Molar mass	322.45 g·mol−1
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Benzylfentanyl (R-4129) is a fentanyl analog. It was temporarily placed in the US Schedule I by emergency scheduling in 1985 due to concerns about its potential for abuse as a designer drug, but this placement was allowed to expire and benzylfentanyl was formally removed from controlled substance listing in 2010, after the DEA's testing determined it to be "essentially inactive" as an opioid. Benzylfentanyl has a K_i of 213nM at the mu opioid receptor, binding around 200x less strongly than fentanyl itself.

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.