ACTL6B
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.[1][2]
Function
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.[2]
Interactions
ACTL6B has been shown to interact with CTBP1.[3]
References
Further reading
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