8A-PDHQ

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8A-PDHQ
Phenyldecahydroquinoline.svg
Systematic (IUPAC) name
8a-phenyldecahydroquinoline
Identifiers
CAS Number 131556-11-1 N
PubChem CID: 131397
ChemSpider 116144 YesY
Chemical data
Formula C15H21N
Molecular mass 215.3339 g/mol
  • C1([C@]23CCCC[C@H]2CCCN3)=CC=CC=C1
  • InChI=1S/C15H21N/c1-2-7-13(8-3-1)15-11-5-4-9-14(15)10-6-12-16-15/h1-3,7-8,14,16H,4-6,9-12H2 YesY
  • Key:QEXADSRMRUUCQJ-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

8a-Phenyldecahydroquinoline (8A-PDHQ) is a high affinity NMDA antagonist developed by a team at Parke Davis in the 1950s.[1] It is a structural analog of Phencyclidine with slightly lower binding affinity than the parent compound. (-)-8a-Phenyldecahydroquinoline has an in vivo potency comparable to that of (+)-MK-801.[2][3]

References

  1. ↑ US Patent 3035059
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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