4,4'-Diapophytoene synthase

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4,4'-diapophytoene synthase
Identifiers
EC number 2.5.1.96
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

4,4'-diapophytoene synthase (EC 2.5.1.96, dehydrosqualene synthase, DAP synthase, C30 carotene synthase, CrtM) is an enzyme with systematic name farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase (4,4'-diapophytoene forming).[1][2][3][4] This enzyme catalyses the following chemical reaction

2 (2E,6E)-farnesyl diphosphate \rightleftharpoons 4,4'-diapophytoene + 2 diphosphate (overall reaction)
(1a) 2 (2E,6E)-farnesyl diphosphate \rightleftharpoons diphosphate + presqualene diphosphate
(1b) presqualene diphosphate \rightleftharpoons 4,4'-diapophytoene + diphosphate

This enzym requires Mn2+. It is preset in Staphylococcus aureus and some other bacteria such as Heliobacillus sp.

References

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External links