Template:PBB/6647

Superoxide dismutase 1, soluble
250px PDB rendering based on 1azv.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1AZV, 1BA9, 1DSW, 1FUN, 1HL4, 1HL5, 1KMG, 1L3N, 1MFM, 1N18, 1N19, 1OEZ, 1OZT, 1OZU, 1P1V, 1PTZ, 1PU0, 1RK7, 1SOS, 1SPD, 1UXL, 1UXM, 2AF2, 2C9S, 2C9U, 2C9V, 2GBT, 2GBU, 2GBV, 2LU5, 2MP3, 2NNX, 2R27, 2V0A, 2VR6, 2VR7, 2VR8, 2WKO, 2WYT, 2WYZ, 2WZ0, 2WZ5, 2WZ6, 2XJK, 2XJL, 2ZKW, 2ZKX, 2ZKY, 3CQP, 3CQQ, 3ECU, 3ECV, 3ECW, 3GQF, 3GTV, 3GZO, 3GZP, 3GZQ, 3H2P, 3H2Q, 3HFF, 3K91, 3KH3, 3KH4, 3LTV, 3QQD, 3RE0, 3T5W, 4A7G, 4A7Q, 4A7S, 4A7T, 4A7U, 4A7V, 4B3E, 4BCY, 4BCZ, 4BD4, 4FF9, 4MCM, 4MCN, 4NIN, 4NIO, 4NIP, 4OH2, 4SOD
Identifiers
Symbols	SOD1 ; ALS; ALS1; HEL-S-44; IPOA; SOD; hSod1; homodimer
External IDs	OMIM: 147450 MGI: 98351 HomoloGene: 392 ChEMBL: 2354 GeneCards: SOD1 Gene
EC number	1.15.1.1
Gene ontology Molecular function • superoxide dismutase activity • copper ion binding • protein binding • zinc ion binding • protein phosphatase 2B binding • identical protein binding • protein homodimerization activity • Rac GTPase binding • chaperone binding Cellular component • extracellular region • extracellular space • nucleus • nucleoplasm • cytoplasm • mitochondrion • mitochondrial intermembrane space • mitochondrial matrix • lysosome • peroxisome • cytosol • plasma membrane • extracellular matrix • dense core granule • cytoplasmic vesicle • dendrite cytoplasm • neuronal cell body • myelin sheath • protein complex • extracellular exosome Biological process • activation of MAPK activity • response to reactive oxygen species • response to superoxide • ovarian follicle development • positive regulation of cytokine production • placenta development • retina homeostasis • response to amphetamine • myeloid cell homeostasis • platelet degranulation • glutathione metabolic process • superoxide metabolic process • cellular iron ion homeostasis • spermatogenesis • embryo implantation • cell aging • blood coagulation • sensory perception of sound • locomotory behavior • anterograde axon cargo transport • retrograde axon cargo transport • regulation of blood pressure • response to heat • response to organic substance • transmission of nerve impulse • removal of superoxide radicals • platelet activation • response to nutrient levels • peripheral nervous system myelin maintenance • positive regulation of superoxide anion generation • regulation of T cell differentiation in thymus • response to carbon monoxide • cellular response to potassium ion • regulation of multicellular organism growth • response to drug • response to hydrogen peroxide • superoxide anion generation • positive regulation of apoptotic process • positive regulation of catalytic activity • regulation of GTPase activity • negative regulation of neuron apoptotic process • response to ethanol • negative regulation of cholesterol biosynthetic process • regulation of protein kinase activity • regulation of organ growth • response to antibiotic • response to copper ion • muscle cell cellular homeostasis • thymus development • response to axon injury • hydrogen peroxide biosynthetic process • regulation of mitochondrial membrane potential • oxidation-reduction process • heart contraction • neurofilament cytoskeleton organization • relaxation of vascular smooth muscle • auditory receptor cell stereocilium organization • cellular response to cadmium ion • cellular response to ATP • reactive oxygen species metabolic process • response to antipsychotic drug • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE SOD1 200642 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6647	20655
Ensembl	ENSG00000142168	ENSMUSG00000022982
UniProt	P00441	P08228
RefSeq (mRNA)	NM_000454	NM_011434
RefSeq (protein)	NP_000445	NP_035564
Location (UCSC)	Chr 21: 31.66 – 31.67 Mb	Chr 16: 90.22 – 90.23 Mb
PubMed search	[1]	[2]