Template:PBB/3458

Interferon, gamma
Interferon, gamma
	Line representation of the crystallographic structure of interferon gamma.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1EKU, 1FG9, 1FYH, 1HIG, 3BES
Identifiers
Symbols	IFNG ; IFG; IFI
External IDs	OMIM: 147570 MGI: 107656 HomoloGene: 55526 GeneCards: IFNG Gene
Gene ontology
Molecular function	• cytokine activity; • interferon-gamma receptor binding;
Cellular component	• extracellular region; • extracellular space; • intracellular; • external side of plasma membrane;
Biological process	• protein import into nucleus, translocation; • negative regulation of transcription from RNA polymerase II promoter; • neutrophil apoptotic process; • regulation of the force of heart contraction; • adaptive immune response; • CD8-positive, alpha-beta T cell differentiation involved in immune response; • apoptotic process; • movement of cell or subcellular component; • humoral immune response; • cell cycle arrest; • cell surface receptor signaling pathway; • positive regulation of cell proliferation; • response to virus; • positive regulation of gene expression; • negative regulation of gene expression; • positive regulation of epithelial cell migration; • cytokine-mediated signaling pathway; • antigen processing and presentation; • neutrophil chemotaxis; • negative regulation of epithelial cell differentiation; • endoplasmic reticulum unfolded protein response; • negative regulation of myelination; • positive regulation of synaptic transmission, cholinergic; • negative regulation of interleukin-17 production; • positive regulation of interleukin-12 production; • positive regulation of interleukin-23 production; • positive regulation of tumor necrosis factor production; • positive regulation of peptidyl-serine phosphorylation of STAT protein; • positive regulation of smooth muscle cell apoptotic process; • positive regulation of T cell proliferation; • response to drug; • positive regulation of tyrosine phosphorylation of Stat1 protein; • defense response to bacterium; • defense response to protozoan; • negative regulation of growth of symbiont in host; • positive regulation of chemokine biosynthetic process; • positive regulation of interleukin-12 biosynthetic process; • positive regulation of MHC class II biosynthetic process; • positive regulation of interleukin-6 biosynthetic process; • positive regulation of nitric oxide biosynthetic process; • positive regulation of neuron differentiation; • positive regulation of osteoclast differentiation; • positive regulation of transcription from RNA polymerase II promoter; • positive regulation of isotype switching to IgG isotypes; • negative regulation of smooth muscle cell proliferation; • positive regulation of interleukin-1 beta secretion; • regulation of insulin secretion; • sensory perception of mechanical stimulus; • positive regulation of membrane protein ectodomain proteolysis; • defense response to virus; • positive regulation of killing of cells of other organism; • interferon-gamma-mediated signaling pathway; • regulation of interferon-gamma-mediated signaling pathway; • positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; • positive regulation of fructose 1,6-bisphosphate metabolic process; • positive regulation of vitamin D biosynthetic process; • positive regulation of calcidiol 1-monooxygenase activity; • cellular response to lipopolysaccharide; • cellular response to interleukin-18; • extrinsic apoptotic signaling pathway; • regulation of neuronal action potential; • positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; • regulation of hepatocyte proliferation;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
Species	Human
Entrez	3458
Ensembl	ENSG00000111537
UniProt	P01579
RefSeq (mRNA)	NM_000619
RefSeq (protein)	NP_000610
Location (UCSC)	Chr 12:; 68.15 – 68.16 Mb
PubMed search	[1]
	v; t; e;

References

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[1]

Template:PBB/3458

References

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