RGS13

Regulator of G-protein signaling 13
Identifiers
Symbols	RGS13 ; MGC17173
External IDs	OMIM: 607190 MGI: 2180585 HomoloGene: 14774 GeneCards: RGS13 Gene
Gene ontology Molecular function • GTPase activator activity Cellular component • nucleus • cytoplasm • cytosol • plasma membrane Biological process • G-protein coupled receptor signaling pathway • termination of G-protein coupled receptor signaling pathway • positive regulation of GTPase activity Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE RGS13 210258 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6003	246709
Ensembl	ENSG00000127074	ENSMUSG00000051079
UniProt	O14921	Q8K443
RefSeq (mRNA)	NM_002927	NM_153171
RefSeq (protein)	NP_002918	NP_694811
Location (UCSC)	Chr 1: 192.64 – 192.66 Mb	Chr 1: 144.14 – 144.18 Mb
PubMed search	[1]	[2]

Regulator of G-protein signaling 13 is a protein that in humans is encoded by the RGS13 gene.

RGS 13 is a member of R4 subfamily of RGS (Regulators of G Protein Signaling) proteins which have only short peptide sequences flanking the RGS domain. RGS 13 suppresses the immunoglobulin E- mediated allergic responses.

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.