P4HB
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Protein disulfide-isomerase is an enzyme that in humans is encoded by the P4HB gene.[1][2][3]
Function
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.[2]
Interactions
P4HB has been shown to interact with UBQLN1,[4] ERO1LB[5][6] and ERO1L.[5][6]
References
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Further reading
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