METTL3

Methyltransferase like 3
Identifiers
Symbols	METTL3 ; IME4; M6A; MT-A70; Spo8
External IDs	OMIM: 612472 MGI: 1927165 HomoloGene: 10501 GeneCards: METTL3 Gene
EC number	2.1.1.62
Gene ontology Molecular function • RNA binding • RNA methyltransferase activity • mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Cellular component • nucleus • nucleoplasm • nuclear speck • MIS complex Biological process • mRNA splicing, via spliceosome • RNA methylation • adenosine to inosine editing • mRNA processing • circadian rhythm • gene expression • stem cell maintenance • primary miRNA processing • mRNA destabilization • mRNA methylation • primary miRNA methylation Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE METTL3 209265 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56339	56335
Ensembl	ENSG00000165819	ENSMUSG00000022160
UniProt	Q86U44	Q8C3P7
RefSeq (mRNA)	NM_019852	NM_019721
RefSeq (protein)	NP_062826	NP_062695
Location (UCSC)	Chr 14: 21.5 – 21.51 Mb	Chr 14: 52.29 – 52.31 Mb
PubMed search	[1]	[2]

N6-adenosine-methyltransferase 70 kDa subunit is an enzyme that in humans is encoded by the METTL3 gene.

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.