HECT domain
| HECT-domain (ubiquitin-transferase) | |||||||||
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| File:PDB 1d5f EBI.jpg
structure of an e6ap-ubch7 complex: insights into the ubiquitination pathway
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| Identifiers | |||||||||
| Symbol | HECT | ||||||||
| Pfam | PF00632 | ||||||||
| InterPro | IPR000569 | ||||||||
| SCOP | 1d5f | ||||||||
| SUPERFAMILY | 1d5f | ||||||||
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In molecular biology, the HECT domain is a protein domain found in ubiquitin-protein ligases. The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus'.[1] Proteins containing this domain at the C terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interacting protein 12 (TRIP12), which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the p53 tumour-suppressor protein for ubiquitin-mediated proteolysis.
References
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This article incorporates text from the public domain Pfam and InterPro IPR000569
