5-IAI

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"NRG-5" redirects here. For the compact food biscuit used for disaster relief, see BP-5 Compact Food.
5-IAI
5-iodo-2-aminoindane.svg
Systematic (IUPAC) name
5-iodo-2,3-dihydro-1H-inden-2-amine
Clinical data
Pregnancy
category
  •  ?
Legal status
  • Uncontrolled
Routes of
administration		 Oral, Insufflated, Rectal
Identifiers
CAS Number 132367-76-1 N
ATC code none
PubChem CID: 131506
ChemSpider 116224 YesY
UNII 7X16E45Y1X YesY
Chemical data
Formula C9H10IN
Molecular mass 259.087 g/mol
  • c2c1CC(N)Cc1ccc2I
  • InChI=1S/C9H10IN/c10-8-2-1-6-4-9(11)5-7(6)3-8/h1-3,9H,4-5,11H2 YesY
  • Key:BIHPYCDDPGNWQO-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

5-Iodo-2-aminoindane (5-IAI) is a drug which acts as a releasing agent of serotonin, norepinephrine, and dopamine.[1] It was developed in the 1990s by a team led by David E. Nichols at Purdue University.[2] 5-IAI fully substitutes for MDMA in rodents and is a putative entactogen in humans.[2] Unlike related aminoindane derivatives like MDAI and MMAI, 5-IAI causes some serotonergic neurotoxicity in rats, but is substantially less toxic than its corresponding amphetamine homologue pIA, with the damage observed barely reaching statistical significance.[1]

See also

References

  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.


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