Minichromosome maintenance
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| MCM2/3/5 family | |||||||||
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Structure of MCM from archaeal M. Thermoautotrophicum.[1]
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| Identifiers | |||||||||
| Symbol | MCM | ||||||||
| Pfam | PF00493 | ||||||||
| Pfam clan | CL0023 | ||||||||
| InterPro | IPR001208 | ||||||||
| SMART | SM00350 | ||||||||
| PROSITE | PDOC00662 | ||||||||
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Potential role of Cdc6 at the initiation of DNA replication.[2]
Minichromosome maintenance protein complex (MCM) is a eukaryotic DNA helicase complex required for the process of DNA replication, specifically the formation and elongation of the replication fork. It is a hexamer of six related polypeptides (MCM2 through MCM7) that form a ring structure.[3][4][5] MCM is a component of the pre-replication complex that forms at the eukryotic origin of replication.
Control of MCM activity in the cell is partly achieved by its sumoylation. During cell cycle levels of chromatin-bound MCM sumoylation oscillate, loss of MCM sumoylation occurs immediately before DNA replication[6]
See also
References
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External links
- Lua error in package.lua at line 80: module 'strict' not found.
- macromolecular structures of MCM at the EM Data Bank(EMDB)
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