B-cell prolymphocytic leukemia
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(Redirected from B cell prolymphocytic leukemia)
| B-cell prolymphocytic leukemia | |
|---|---|
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| Classification and external resources | |
| Specialty | Hematology and oncology |
| ICD-O | M9833/3 |
| Patient UK | B-cell prolymphocytic leukemia |
| MeSH | D054403 |
B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.
It can involve deletions from chromosome 11 and chromosome 13.[1]
It has been suggested that some cases may represent a variant of mantle cell lymphoma.[2]
It has a relatively poor prognosis.[3]
Markers
A case has been described as CD20+, CD22+, and CD5-.[4]
It can also be CD5+.[5]
Another case was described as CD45+, CD19+, CD20+, CD5+, HLA-DR+, CD10-, CD23+/-, CD38+ and FMC7-.[6]
Treatment
Splenic irradiation has been used in the treatment.[7]
References
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